100 compounds. 200+ peer-reviewed studies.

The GLP-1 that started it all — weekly injection, durable weight loss, restored insulin signaling.

The first dual incretin — superior to GLP-1 alone on weight, glucose, and metabolic markers.

First-generation GLP-1 — daily injection, robust safety record, foundational to the category.

Triple agonist — three receptors, one molecule, the highest weight loss efficacy ever recorded.

Amylin meets GLP-1 — dual mechanism that addresses what semaglutide alone misses.

The foundational male hormone — replacement therapy when endogenous production fails.

The TRT companion — preserves testicular function and fertility during testosterone replacement.

Direct GH replacement — most powerful intervention for body composition.

The most-prescribed drug in America — synthetic T4 for hypothyroidism.

The only molecule shown to extend lifespan in every species tested — yeast to mammals.

Most-prescribed diabetes drug, repurposed as the first FDA-approved aging trial.

Lifespan-extending diabetes drug — slows carb absorption, blunts post-meal glucose.

Off-label utility player — autoimmune modulation, pain reduction, HPA-axis support.

FDA-approved GHRH analog with the strongest visceral fat reduction data.

FDA-approved melanocortin agonist — sexual desire treatment that bypasses vascular pathways.

First-generation GHRH analog — short half-life produces clean, physiological GH pulses.

Long-acting GHRH analog — DAC modification extends half-life to 6+ days.

The pulsatile cousin of CJC-1295 — short half-life, clean pulses, ideal stack with ipamorelin.

The cleanest GHRP — selective GH release with no significant cortisol or prolactin elevation.

Stronger GH release than ipamorelin, with cortisol and appetite trade-offs.

The only orally bioavailable GH secretagogue — sustained GH/IGF-1 elevation in pill form.

The most-discussed peptide in biohacking — strong preclinical data, limited human trials.

Tissue regeneration peptide — modulates actin, drives cell migration, accelerates wound healing.

The copper peptide — modulates 4,000+ genes, drives collagen synthesis, resets aged tissue.

FDA-approved for interstitial cystitis, off-label for joint and cartilage support.

Russian-developed anxiolytic — non-sedating, non-addictive alternative to benzodiazepines.

Russian nootropic peptide — upregulates BDNF, NGF, dopaminergic signaling.

Pig-brain-derived peptide cocktail with strong stroke recovery and Alzheimer's data.

Angiotensin IV analog with potent synaptogenic activity — preclinical data 7 orders stronger than BDNF.

Cerebrolysin-derived peptide — promotes new neuron formation in adult hippocampus.

The mitochondrial cardiolipin stabilizer — restores energy production in damaged mitochondria.

An exercise mimetic encoded by mitochondrial DNA — activates AMPK signaling.

Neuroprotective mitochondrial peptide — protects against amyloid-beta toxicity.

The coenzyme that powers mitochondrial function and DNA repair — direct administration.

The Sinclair-popularized NAD+ precursor — direct conversion to NAD+ in cells.

Most-studied NAD+ precursor in humans — Tru Niagen has 30+ clinical trials.

FDA-orphan-drug-approved immune modulator — restores T-cell function and DC maturation.

Russian thymic peptide complex with Khavinson lineage — immune restoration.

Three-amino-acid anti-inflammatory peptide — gut-targeted with strong IBD/colitis preclinical data.

The body's own broad-spectrum antimicrobial — biofilm disruption, chronic infection applications.

The CIRS / mold illness peptide — vasoactive and immunomodulatory effects.

Khavinson telomerase tetrapeptide — pineal-derived, telomere-supporting.

Pineal-derived tripeptide — neuroprotective, Khavinson bioregulator framework.

Khavinson cardiac tissue peptide — heart health support, cyclical dosing.

Khavinson vascular peptide — endothelial function and circulation support.

GH fragment with lipolysis effects but without GH systemic effects.

Lipolytic GH fragment — same molecule family as AOD-9604.

NNMT inhibitor — adipose-targeted metabolic compound.

Delta Sleep-Inducing Peptide — supports sleep architecture and REM cycles.

The body's master antioxidant — liver detox, immune support, oxidative stress reduction.

FDA-approved α-MSH analog — pigmentation, EPP photoprotection.

HPG axis stimulator — supports endogenous testosterone, fertility research.

5-α reductase inhibitor — gold standard for androgenic alopecia.

Dual 5-α reductase inhibitor — more potent than finasteride.

Low-dose oral vasodilator — hair regrowth without scalp application.

Adrenal precursor hormone — sex hormone substrate, declines with age.

Master neurosteroid — cognitive support, GABA modulation, downstream hormone substrate.

Bioidentical progesterone — sleep, anxiety, hormone balance.

Bioidentical estrogen — female longevity hormone, bone density, cardiovascular support.

Mayo Clinic senolytic combo — removes senescent cells.

Polyphenol senolytic — removes senescent cells in preclinical models.

Peptide senolytic — disrupts FOXO4-p53 interaction in senescent cells.

Polyamine — induces autophagy, found in wheat germ and aged cheese.

Mitophagy inducer — Amazentis Mitopure, generated from pomegranate ellagitannins.

SIRT1 activator — Sinclair lab classic, mechanism well-studied.

Resveratrol analog with better bioavailability — same SIRT1 pathway, longer half-life.

Flavonoid — senolytic component (D+Q stack), anti-inflammatory, mast cell stabilizer.

Flavone CD38 inhibitor — boosts NAD+ via different pathway than NMN/NR.

Anti-inflammatory polyphenol — Meriva/Theracurmin formulations for bioavailability.

Green tea catechin — antioxidant, mild metabolic effects, take with food.

Nrf2 activator from broccoli sprouts — phase 2 detox, antioxidant defense.

Carotenoid antioxidant — strong antioxidant capacity, skin photoprotection, eye health.

Mitochondrial electron transport — energy production, statin co-factor.

Pyrroloquinoline Quinone — mitochondrial biogenesis, often paired with CoQ10.

Low-dose alternative electron carrier — mitochondrial bypass, stains everything blue.

AMPK activator — natural metformin analog. Glucose, cholesterol, gut microbiome.

Mitochondrial antioxidant from mushrooms — emerging longevity epidemiology data.

Only magnesium that crosses blood-brain barrier — sleep, cognition, recovery.

Most-studied supplement on Earth — strength, cognition, cellular energy.

Conditional amino acid — 2023 Science paper showed lifespan extension in animals.

Amino acid — methylation, sleep quality, glutathione precursor.

Trimethylglycine — methyl donor, supports homocysteine metabolism.

Anti-glycation dipeptide — opposes AGE formation, muscle and cardiovascular health.

Acetyl-L-Carnitine — mitochondrial fatty acid transport, cognition support.

Choline source — most bioavailable cholinergic, cognition + GH support.

Choline + cytidine — choline source plus dopamine support pathway.

Hericium erinaceus — NGF stimulation, cognitive support.

Adaptogenic herb — memory, anxiolytic, builds over 8-12 weeks.

Stress adaptogen — energy, mood, cognitive resilience under fatigue.

Diabetes drug with off-label longevity interest — cardiac, renal, metabolic benefits.

ARB blood pressure med with PPARγ activity — investigational longevity application.

MMP modulator at sub-antibiotic dose — connective tissue, periodontal support.

ITP lifespan extension in male mice — minimal feminizing effects vs 17β estradiol.

Longevity hormone — declining levels correlate with age-related decline.

Anti-aging factor — controversial young-blood research.

Myostatin inhibitor — muscle growth research, gene therapy parallels.

Microdose lithium — mood, longevity epidemiology in tap water studies.

Selective androgen receptor modulator — most-studied SARM. Research only, not approved.

AR modulator — bone and muscle research. Research compound, not approved for human use.

Joint viscosupplementation — restores synovial fluid properties in osteoarthritis.