Hormonal Optimization

Pregnenolone

Research / preclinical

Master neurosteroid — cognitive support, GABA modulation, downstream hormone substrate.

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Mechanism

Master neurosteroid. Master neurosteroid — cognitive support, GABA modulation, downstream hormone substrate. For full mechanism, dosing protocol, and stacking guidance, ask the AI Advisor or open the compound in-app.

Peer-Reviewed Studies (2)

Pregnenolone for Cognitive Decline

Psychoneuroendocrinology · 2014

Improved memory in subjects with mild cognitive impairment.

PubMed PMID 24650552 →

Neurosteroids and GABA-A Modulation

Pharmacol Rev · 2003

Reviewed neurosteroid pharmacology and CNS effects.

PubMed PMID 12869632 →

Related Compounds

Testosterone (TRT)

The foundational male hormone — replacement therapy when endogenous production fails.

HCG

The TRT companion — preserves testicular function and fertility during testosterone replacement.

HGH (Somatropin)

Direct GH replacement — most powerful intervention for body composition.

Levothyroxine

The most-prescribed drug in America — synthetic T4 for hypothyroidism.

DHEA

Adrenal precursor hormone — sex hormone substrate, declines with age.

Progesterone (bioidentical)

Bioidentical progesterone — sleep, anxiety, hormone balance.