Mitochondrial

Berberine

Research / preclinical

AMPK activator — natural metformin analog. Glucose, cholesterol, gut microbiome.

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Mechanism

AMPK activator. AMPK activator — natural metformin analog. Glucose, cholesterol, gut microbiome. For full mechanism, dosing protocol, and stacking guidance, ask the AI Advisor or open the compound in-app.

Peer-Reviewed Studies (2)

Berberine vs Metformin in T2D Comparison

Metabolism · 2008

Comparable glucose-lowering efficacy to metformin.

PubMed PMID 18442638 →

Berberine and Lipid Metabolism Meta-Analysis

Phytomedicine · 2018

Significantly reduced LDL and triglycerides across studies.

PubMed PMID 29655642 →

Related Compounds

SS-31 (Elamipretide)

The mitochondrial cardiolipin stabilizer — restores energy production in damaged mitochondria.

MOTS-c

An exercise mimetic encoded by mitochondrial DNA — activates AMPK signaling.

Humanin

Neuroprotective mitochondrial peptide — protects against amyloid-beta toxicity.

CoQ10 / Ubiquinol

Mitochondrial electron transport — energy production, statin co-factor.

PQQ

Pyrroloquinoline Quinone — mitochondrial biogenesis, often paired with CoQ10.

Methylene Blue (low-dose)

Low-dose alternative electron carrier — mitochondrial bypass, stains everything blue.