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Home / Compounds / Longevity Pharmaceuticals

Longevity Pharmaceuticals

8 compounds · 18 peer-reviewed studies

Rapamycin

FDA

The only molecule shown to extend lifespan in every species tested — yeast to mammals.

Metformin

FDA

Most-prescribed diabetes drug, repurposed as the first FDA-approved aging trial.

Acarbose

FDA

Lifespan-extending diabetes drug — slows carb absorption, blunts post-meal glucose.

Low-Dose Naltrexone (LDN)

FDA

Off-label utility player — autoimmune modulation, pain reduction, HPA-axis support.

SGLT2 Inhibitors (Empagliflozin)

Tier 3

Diabetes drug with off-label longevity interest — cardiac, renal, metabolic benefits.

Telmisartan

Tier 3

ARB blood pressure med with PPARγ activity — investigational longevity application.

Doxycycline (low-dose)

Tier 3

MMP modulator at sub-antibiotic dose — connective tissue, periodontal support.

17α-Estradiol

Tier 3

ITP lifespan extension in male mice — minimal feminizing effects vs 17β estradiol.

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