Longevity Pharmaceuticals
Rapamycin
FDAThe only molecule shown to extend lifespan in every species tested — yeast to mammals.
Metformin
FDAMost-prescribed diabetes drug, repurposed as the first FDA-approved aging trial.
Acarbose
FDALifespan-extending diabetes drug — slows carb absorption, blunts post-meal glucose.
Low-Dose Naltrexone (LDN)
FDAOff-label utility player — autoimmune modulation, pain reduction, HPA-axis support.
SGLT2 Inhibitors (Empagliflozin)
Tier 3Diabetes drug with off-label longevity interest — cardiac, renal, metabolic benefits.
Telmisartan
Tier 3ARB blood pressure med with PPARγ activity — investigational longevity application.
Doxycycline (low-dose)
Tier 3MMP modulator at sub-antibiotic dose — connective tissue, periodontal support.
17α-Estradiol
Tier 3ITP lifespan extension in male mice — minimal feminizing effects vs 17β estradiol.