Rapamycin
FDA approvedAlso known as: Rapamune
The only molecule shown to extend lifespan in every species tested — yeast to mammals.
Mechanism
mTOR inhibitor. The only molecule shown to extend lifespan in every species tested — yeast to mammals. For full mechanism, dosing protocol, and stacking guidance, ask the AI Advisor or open the compound in-app.
Peer-Reviewed Studies (3)
Rapamycin Fed Late in Life Extends Lifespan in Heterogeneous Mice
9-14% median lifespan extension in NIA ITP.
PubMed PMID 19587680 →mTOR Inhibition Improves Immune Function in Elderly
Mannick et al.: ~20% improvement in flu vaccine response.
PubMed PMID 25540326 →Rapamycin and the Dog Aging Project Interim Results
Improved cardiac function in companion dogs.
PubMed PMID 36445578 →