Metformin
FDA approvedAlso known as: Glucophage, Fortamet
Most-prescribed diabetes drug, repurposed as the first FDA-approved aging trial.
Mechanism
Biguanide / AMPK activator. Most-prescribed diabetes drug, repurposed as the first FDA-approved aging trial. For full mechanism, dosing protocol, and stacking guidance, ask the AI Advisor or open the compound in-app.
Peer-Reviewed Studies (3)
Mortality in Diabetics on Metformin vs Sulphonylurea
180,000+ patients: T2D on metformin had 15% lower mortality than non-diabetics.
PubMed PMID 25041462 →Metformin as a Tool to Target Aging
Established TAME trial rationale: AMPK, mTOR, mitochondrial effects.
PubMed PMID 27304504 →Metformin and Cancer Prevention Meta-Analysis
Reduced cancer incidence in T2D patients on metformin.
PubMed PMID 20570883 →