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Senolytics

5 compounds · 10 peer-reviewed studies

Dasatinib + Quercetin (D+Q)

Tier 3

Mayo Clinic senolytic combo — removes senescent cells.

Fisetin

Tier 3

Polyphenol senolytic — removes senescent cells in preclinical models.

FOXO4-DRI

Tier 3

Peptide senolytic — disrupts FOXO4-p53 interaction in senescent cells.

Spermidine

Tier 3

Polyamine — induces autophagy, found in wheat germ and aged cheese.

Urolithin A (Mitopure)

Tier 3

Mitophagy inducer — Amazentis Mitopure, generated from pomegranate ellagitannins.

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