GH Secretagogues

MK-677 (Ibutamoren)

Compounding-legal

The only orally bioavailable GH secretagogue — sustained GH/IGF-1 elevation in pill form.

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Mechanism

Oral ghrelin agonist. The only orally bioavailable GH secretagogue — sustained GH/IGF-1 elevation in pill form. For full mechanism, dosing protocol, and stacking guidance, ask the AI Advisor or open the compound in-app.

Peer-Reviewed Studies (2)

MK-677 Increases GH/IGF-1 in Healthy Older Adults

Ann Intern Med · 2008

Daily 25mg restored IGF-1 to young adult mean levels.

PubMed PMID 19075238 →

Long-Term MK-677 in Hip Fracture Recovery

Bone · 2014

Improved muscle strength and functional capacity in elderly.

PubMed PMID 24787919 →

Related Compounds

Tesamorelin

FDA-approved GHRH analog with the strongest visceral fat reduction data.

Sermorelin

First-generation GHRH analog — short half-life produces clean, physiological GH pulses.

CJC-1295 (with DAC)

Long-acting GHRH analog — DAC modification extends half-life to 6+ days.

Mod GRF 1-29 (CJC-1295 no DAC)

The pulsatile cousin of CJC-1295 — short half-life, clean pulses, ideal stack with ipamorelin.

Ipamorelin

The cleanest GHRP — selective GH release with no significant cortisol or prolactin elevation.

GHRP-2

Stronger GH release than ipamorelin, with cortisol and appetite trade-offs.