Longevity Polyphenols

Resveratrol

Research / preclinical

SIRT1 activator — Sinclair lab classic, mechanism well-studied.

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Mechanism

SIRT1 activator polyphenol. SIRT1 activator — Sinclair lab classic, mechanism well-studied. For full mechanism, dosing protocol, and stacking guidance, ask the AI Advisor or open the compound in-app.

Peer-Reviewed Studies (2)

Resveratrol Improves Health and Survival of Mice on High-Calorie Diet

Nature · 2006

Sinclair lab landmark study showing health benefits.

PubMed PMID 17086191 →

Resveratrol Human Trials Meta-Analysis

Aging Cell · 2015

Mixed effects in humans; mechanism preserved across studies.

PubMed PMID 25865508 →

Related Compounds

Pterostilbene

Resveratrol analog with better bioavailability — same SIRT1 pathway, longer half-life.

Quercetin

Flavonoid — senolytic component (D+Q stack), anti-inflammatory, mast cell stabilizer.

Apigenin

Flavone CD38 inhibitor — boosts NAD+ via different pathway than NMN/NR.

Curcumin (Meriva)

Anti-inflammatory polyphenol — Meriva/Theracurmin formulations for bioavailability.

EGCG

Green tea catechin — antioxidant, mild metabolic effects, take with food.

Sulforaphane

Nrf2 activator from broccoli sprouts — phase 2 detox, antioxidant defense.