Longevity Polyphenols

Sulforaphane

Research / preclinical

Nrf2 activator from broccoli sprouts — phase 2 detox, antioxidant defense.

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Mechanism

Nrf2 activator. Nrf2 activator from broccoli sprouts — phase 2 detox, antioxidant defense. For full mechanism, dosing protocol, and stacking guidance, ask the AI Advisor or open the compound in-app.

Peer-Reviewed Studies (2)

Sulforaphane Activates Nrf2 in Human Subjects

Cancer Prev Res · 2013

Demonstrated Nrf2 pathway activation with broccoli sprout extract.

PubMed PMID 23434473 →

Sulforaphane in Autism Spectrum Disorder

PNAS · 2014

Improved behavioral symptoms in young men with ASD.

PubMed PMID 25313065 →

Related Compounds

Resveratrol

SIRT1 activator — Sinclair lab classic, mechanism well-studied.

Pterostilbene

Resveratrol analog with better bioavailability — same SIRT1 pathway, longer half-life.

Quercetin

Flavonoid — senolytic component (D+Q stack), anti-inflammatory, mast cell stabilizer.

Apigenin

Flavone CD38 inhibitor — boosts NAD+ via different pathway than NMN/NR.

Curcumin (Meriva)

Anti-inflammatory polyphenol — Meriva/Theracurmin formulations for bioavailability.

EGCG

Green tea catechin — antioxidant, mild metabolic effects, take with food.